Low back pain is a common problem that affects millions of people worldwide — especially older women. While the causes of low back pain can be varied, new research suggests that estrogen may play a role in its development and severity. A recent review published in Bone Research reported that estrogen receptors are present in the intervertebral discs and facet joints. These two key areas of the spine are often affected by low back pain. This suggests that estrogen may have a direct impact on the health of these tissues.